Fibromyalgia is a complex condition. There is much concerning it that remains unknown. Research on fibromyalgia includes:

• Studies are under way by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) regarding fibromyalgia and low levels of the hormone cortisol. Researchers are studying the function of the adrenal glands (responsible for producing cortisol) in fibromyalgia patients. Initial results indicate that individuals with low levels of cortisol may experience many symptoms of fibromyalgia.

In addition, scientists in Germany have recently found that prenatal stress may permanently impair the fetus’ production of cortisol and that girls born after a stressful pregnancy may face increased risk of developing fibromyalgia in adulthood.

• Clinical studies supported by NIAMS are investigating pain mechanisms in fibromyalgia. Some of these are comparing the pain mechanisms in fibromyalgia and lower back pain. Others are looking into the effects of female reproductive hormones and reduced blood flow to parts of the brain that deal with pain or increased sensitivity to pain.
  
  
• NIAMS is funding a clinical trial to determine the effectiveness of combining antidepressants in the treatment of fibromyalgia.
  
  
• The National Institutes of Health is investigating the effectiveness of acupuncture in the treatment of fibromyalgia.

Research projects dealing with the role of behavioral factors in fibromyalgia are being funded by NIAMS. These projects are evaluating the effects of cognitive behavioral therapy and physical exercise training to determine if these therapies may be more effective together than alone.